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Cefotaxime sodium C16H16N5NaO7S2 - PubChem

Cefotaxime sodium C16H16N5NaO7S2 - PubChem. National Center for Biotechnology Information. 8600 Rockville Pike, Bethesda, MD, 20894 USA. Contact. Policies. FOIA. National Library of Medicine. National Institutes of Health. Department of Health and Human Services.

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Cefotaxime C16H17N5O7S2 - PubChem

Cefotaxime is a cephalosporin compound having acetoxymethyl and [2- (2-amino-1,3-thiazol-4-yl)-2- (methoxyimino)acetyl]amino side groups. It has a role as a drug allergen and an antibacterial drug. It is a member of 1,3-thiazoles, an oxime O-ether and a cephalosporin. It is a conjugate acid of a cefotaxime

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Cefotaxime Sodium CAS#64485-93-4 Cephalosporin ...

Cefotaxime Sodium is the sodium salt form of cefotaxime, a beta-lactam, third-generation cephalosporin antibiotic with bactericidal activity. Cefotaxime sodium binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linking of peptidoglycan chains necessary for bacterial cell wall ...

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EP0799232A1 - Production of cefotaxime and new sodium ...

cefotaxime compound acetone sodium salt Prior art date 1994-12-23 Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) Ceased Application number EP95942724A Other languages German (de) French (fr) Inventor ...

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EP1704153A2 - Improved process for the production of ...

A process for the production of 7-[2-(2-amino-4-thiazolyl)-2-syn-methoxyimino-acetamido]-3-acetoxymethyl-3-cephem-4-carboxylic acid (Cefotaxime) in aqueous isopropyl alcohol is discussed. The synthesis is effected by condensing 7-aminocephalosporanic acid (7-ACA) with 2-(2-chloroacetamidothiazol-4-yl)-2-syn-methoxyiminoacetyl chloride followed by deblocking amino

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Cefotaxime - an overview ScienceDirect Topics

Sharon S. Castle, in xPharm: The Comprehensive Pharmacology Reference, 2007 Cefotaxime; Claforan (trade); 7 [2 (2 aminothiazol 4yl)glyoxylamido] 3 hydroxymethyl 2 cephem 2 carboxylic acid alpha (o methyloxime) acetate; 7 [2 (2 amino 4 thiazolyl) 2methoxyiminoacetamido]cephalosporanic acid; 7 [2 (2 aminothiazol 4 yl) 2methoxyiminoacetamido]cephalosporanic acid; cefatoxamine; cefotaxime sodium ...

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Cefotaxime sodium: A new and efficient corrosion inhibitor ...

May 01, 2009  High inhibition efficiency of cefotaxime sodium is attributed to presence of free NH 2 group which gets strongly protonated in hydrochloric acid solution. Week protonation of pyridine N of cefatrexyl gives low inhibition efficiency. 4. ConclusionThe inhibition efficiency of cefotaxime sodium increases with increase in the inhibitor concentration.

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Cefotaxime Sigma-Aldrich

Cefotaxime acid. Cefotaxime acid. Synonyms: Cefotaxime. CAS Number: 63527-52-6. Molecular Weight: 455.47. EC Number: 264-299-1. Empirical Formula ... Cefotaxime sodium. Synonyms: Cefotaxime sodium salt, Cefotaxim sodium salt. CAS Number: 64485-93-4. Molecular Weight: 477.45. Beilstein Registry Number: 5711411. Empirical Formula (Hill Notation ...

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Cefotaxime: Uses, Interactions, Mechanism of Action ...

724 行  Cefotaxime may decrease the excretion rate of Sodium aurothiomalate which could result in

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Cefotaxima C16H17N5O7S2 - PubChem

Benaxima. Biosint. Cefotaxim. Cefotaxime. Cefotaxime Sodium. Cefradil. Cephotaxim. Claforan. Fotexina. HR 756. HR-756. HR756. Kendrick. Klaforan. Primafen. Ru 24756 ...

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Quality of cefotaxime sodium preparations

Cefotaxime sodium (CAS 64485-93-4) is a semisynthetic cephalosporin derivative belonging to the third-generation cephalosporins. Owing to its broad antibacterial activity and its high resistance to beta-lactamases it can be used for a large variety of infections. In the present study the quality sta

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CN1394863A - Method for synthesizing cefotaxime sodium ...

The present invention discloses a method for synthesizing cefotaxime sodium, and said method includes the following steps: placing 7-amino cephaloalkyl acid (7-ACA) and benzothiazol active ester (MEAM) in organic solvent, using triethylamine as condensation agent, under the catalysis of phase transfer catalyst making them produce condensation reaction to obtain cefotaxime acid, and making

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Process for the production of cefotaxime sodium - Justia

Jul 17, 2006  Cefotaxime acid is converted to cefotaxime sodium (Formula VII); in a mixture of methanol and ethyl acetate in presence of triethylamine and sodium-2-ethylhexanonate. The product is precipitated by addition of excess ethyl acetate which on filtration provides final

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Cefotaxime Sodium CAS#64485-93-4 Cephalosporin ...

Cefotaxime Sodium is the sodium salt form of cefotaxime, a beta-lactam, third-generation cephalosporin antibiotic with bactericidal activity. Cefotaxime sodium binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linking of peptidoglycan chains necessary for bacterial cell wall ...

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Cefotaxime - an overview ScienceDirect Topics

Sharon S. Castle, in xPharm: The Comprehensive Pharmacology Reference, 2007 Cefotaxime; Claforan (trade); 7 [2 (2 aminothiazol 4yl)glyoxylamido] 3 hydroxymethyl 2 cephem 2 carboxylic acid alpha (o methyloxime) acetate; 7 [2 (2 amino 4 thiazolyl) 2methoxyiminoacetamido]cephalosporanic acid; 7 [2 (2 aminothiazol 4 yl) 2methoxyiminoacetamido]cephalosporanic acid; cefatoxamine; cefotaxime sodium ...

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CLAFORAN Sterile (cefotaxime for injection, USP) and ...

mg to the 1 g and 2 g cefotaxime dosages, respectively). The injections are buffered with sodium citrate hydrous, USP. The pH is adjusted with hydrochloric acid and may be adjusted with sodium hydroxide. The plastic container is fabricated from a specially designed multilayer plastic (PL 2040). Solutions are in

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Cefotaxime sodium: A new and efficient corrosion inhibitor ...

May 01, 2009  High inhibition efficiency of cefotaxime sodium is attributed to presence of free NH 2 group which gets strongly protonated in hydrochloric acid solution. Week protonation of pyridine N of cefatrexyl gives low inhibition efficiency. 4. ConclusionThe inhibition efficiency of cefotaxime sodium increases with increase in the inhibitor concentration.

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Synthesis and effect of pegylation on citric acid ...

Synthesis and effect of pegylation on citric acid dendritic nano architectures anchored with cefotaxime sodium J Photochem Photobiol B. 2019 Dec;201:111683. doi: 10.1016/j.jphotobiol.2019.111683. Epub 2019 Nov 6. Authors Viswanath Valikala 1 ...

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Cefotaxime - Wikipedia

Cefotaxime is an antibiotic used to treat a number of bacterial infections. Specifically it is used to treat joint infections, pelvic inflammatory disease, meningitis, pneumonia, urinary tract infections, sepsis, gonorrhea, and cellulitis. It is given either by injection into a vein or muscle.. Common side effects include nausea, allergic reactions, and inflammation at the site of injection.

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Cefotaxime sodium Antibacterial 陶术生物

Cefotaxime sodium-64485-93-4 Cefotaxime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram positive and Gram negative bacteria. In most cases, it is considered to be equivalent to ceftriaxone in terms of safety and efficacy. Cefotaxime sodium is marketed under various trade names including Claforan (Sanofi ...

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Cefotaxime sodium - wikidoc

There is limited information regarding Cefotaxime sodium Clinical Studies in the drug label. How Supplied. Sterile Cefotaxime for Injection, USP, is a dry off-white to pale yellow crystalline powder supplied in vials and bottles containing cefotaxime sodium as follows: 500 mg cefotaxime (free acid equivalent) vials in packages of 10 (NDC 0143 ...

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Cefotaxime: Uses, Interactions, Mechanism of Action ...

Cefotaxime may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level. Sodium citrate The therapeutic efficacy of Sodium citrate can be decreased when used in combination with Cefotaxime.

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Novel spectrophotometric determination of Valacyclovir and ...

cefotaxime with 1, 2- napthaquinone-4- sulfonic acid sodium (NQS) in alkaline media to yield orange colored products respectively. Valacyclovir and cefotaxime showed maximum absorbance at 495nm and 475nm with linearity was observed in the concentration range of

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CEFOTAXIME FOR INJECTION, USP

Cefotaxime for Injection, USP contains approximately 50.5 mg (2.2 mEq) of sodium per gram of cefotaxime activity. Solutions of Cefotaxime for Injection, USP range from very pale yellow to light amber depending on the concentration and the diluent used. The pH of the injectable solutions usually ranges from 5.0 to 7.5.

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DailyMed - CEFOTAXIME injection, powder, for solution

Nov 26, 2019  Sterile Cefotaxime for injection, USP is a dry off-white to pale yellow crystalline powder supplied in vials containing cefotaxime sodium as follows: 500 mg cefotaxime (free acid equivalent) in vials in packages of: Package of 1 NDC 64679-947-01. Package of 10 NDC 64679-947-02

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Dilution Cefotaxime - GlobalRPH

Sep 03, 2017  Sterile CLAFORAN is a dry off-white to pale yellow crystalline powder supplied in vials containing cefotaxime sodium as follows: 1 g cefotaxime (free acid equivalent) in vials in packages of 10 (NDC 0039-0018-49). 2 g cefotaxime (free acid equivalent) in vials in

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CLAFORAN Sterile (cefotaxime for injection, USP) and ...

Cefotaxime sodium also demonstrates in vitro activity against the following microorganisms but the clinical significance is unknown.Cefotaxime sodium exhibits in vitro minimal inhibitory concentrations (MICs) of 8 mcg/mL or less against most (≥90%) strains of the following microorganisms; however, the

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CEFOTAXIME SODIUM

Searches without any special characters (listed below) will return items that contain the exact value(s) entered in the search field.

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IMPORTANT PRESCRIBING INFORMATION Temporary

Cefotaxime sodium for Injection, BP in the dry state should be stored at room temperature (15-25°C), protected from light and heat. The dry powder as well as solutions tend to darken, depending ...

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Cefotaxime sodium Sigma-Aldrich

Showing 1-4 of 4 results for "cefotaxime sodium" Advanced Search. Structure Search. Relevance. Compare. Cefotaxime sodium. Cefotaxime sodium. Synonyms: Cefotaxime sodium salt, Cefotaxim sodium salt. CAS Number: 64485-93-4. Molecular Weight: 477.45. Beilstein Registry Number: 5711411. Empirical Formula (Hill Notation):

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Synthesis and effect of pegylation on citric acid ...

Synthesis and effect of pegylation on citric acid dendritic nano architectures anchored with cefotaxime sodium J Photochem Photobiol B. 2019 Dec;201:111683. doi: 10.1016/j.jphotobiol.2019.111683. Epub 2019 Nov 6. Authors Viswanath Valikala 1 ...

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Novel spectrophotometric determination of Valacyclovir and ...

cefotaxime with 1, 2- napthaquinone-4- sulfonic acid sodium (NQS) in alkaline media to yield orange colored products respectively. Valacyclovir and cefotaxime showed maximum absorbance at 495nm and 475nm with linearity was observed in the concentration range of

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Cefotaxime Sodium, chemical structure, molecular formula ...

in which C is the concentration,in mg per mL,of USP Cefotaxime Sodium RS in the Standard preparation, P is the designated content,in µg per mg,of cefotaxime (C 16 H 17 N 5 O 7 S 2)in USP Cefotaxime Sodium RS, W is the weight,in mg,of Cefotaxime Sodium taken to prepare the Assay preparation,and r U and r S are the cefotaxime peak area responses ...

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Cefotaxime sodium supplier CasNO.64485-93-4

Cefotaxime sodium: EINECS: 264-915-9 CAS No. 64485-93-4: Density: 1.8 g/cm 3 : PSA: 229.88000 LogP-1.04720 Solubility: Soluble in water. Melting Point: 162-163 °C: Formula: C 16 H 16 N 5 NaO 7 S 2: Boiling Point: Molecular Weight: 477.48 Flash Point: Transport Information: Appearance

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Cefotaxime Sodium-impurities Pharmaffiliates

Cefotaxime Sodium is used to treat a wide variety of bacterial infections. It is an antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram positive and Gram negative bacteria.. Reference standards of Cefotaxime Sodium API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below

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Solubility of Cefotaxime Sodium in Ethanol + Water ...

May 09, 2014  Aimed at exploring the influence of acetic acid on crystallization thermodynamics of cefotaxime sodium (CTX), the solubility of CTX in ethanol + water mixtures under acetic acid conditions at various temperatures are measured by a gravimetrical method. Different from the solubility curve when acetic acid is absent, the solubility curves of CTX under acetic acid conditions have a

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CAS No.64485-93-4,Cefotaxime sodium Suppliers

Cefotaxime sodium Manufacturer/High quality/Best price/In stock. Min.Order: 1 Kilogram FOB Price: USD $ 3.0-3.0/Kilogram Dayangchem's RD center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of

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